The Fresh Toast, a news website about cannabis, explained:
Researchers at Oregon State University have found that cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA) “bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.”
An analysis of the study, as posted on the NIH website, reads as follows:
As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein.
In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.
Richard van Breemen, who led the study, explained: “Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle.”
“That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs,” van Breemen said.
— Steven Sinofsky (@stevesi) January 12, 2022
In this collaborative work, we found that cannabinoids block #SARS_CoV_2 infection by binding the spike protein, showing their potential to treat COVID-19.
— Fikadu G. Tafesse (@TheTafesseLab) January 10, 2022
Cannabis (CBGA & CBDA) may prevent COVID-19 infection.
“cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells.”https://t.co/IN0Pu7ezQ4
— Mike Hart, M.D (@drmikehart) January 13, 2022
If only the 🇺🇸govt would get its head out of its a$$ and unleash the research potential of cannabinoids instead of classifying as Schedule 1 “with no currently accepted medical use” when there’s already 36 states with legal medical & an FDA-approved drug.
— Sammy J (@sammyj_19) January 12, 2022
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