As the most reliable and balanced news aggregation service on the internet, DML News App offers the following information published by The Guardian:
We all know that person who, despite their entire household catching Covid-19, has never tested positive for the disease. Now scientists have found an explanation, showing that a proportion of people experience “abortive infection” in which the virus enters the body but is cleared by the immune system’s T-cells at the earliest stage meaning that PCR and antibody tests record a negative result.
About 15% of healthcare workers who were tracked during the first wave of the pandemic in London, England, appeared to fit this scenario.
The article goes on to state the following:
The discovery could pave the way for a new generation of vaccines targeting the T-cell response, which could produce much longer lasting immunity, scientists said.
The report explains that during the first wave of the covid-19 pandemic, a study monitored healthcare workers for signs of infection and how their immune system responded.
The healthcare workers all had a “high risk of exposure,” but 58 never tested positive for Covid-19. Blood samples taken from these healthcare workers showed “they had an increase in T-cells that reacted against Covid-19, compared with samples taken before the pandemic took hold and compared with people who had not been exposed to the virus at all.”
The study indicated the healthcare workers’ immune systems had developed a memory from other seasonal virus such as common colds, which protected them from Covid-19.
The Guardian quotes Leo Swadling, an immunologist at University College London and lead author of the paper, as explaining: “Everyone has anecdotal evidence of people being exposed but not succumbing to infection. What we didn’t know is whether these individuals really did manage to completely avoid the virus or whether they naturally cleared the virus before it was detectable by routine tests.”
“These pre-existing T-cells are poised ready to recognize SARS-CoV-2,” Swadling also said.
The study also compared the lasting effects of the T-cell arm of the immune system, compared to that of the Covid-19 vaccines, saying the vaccine’s neutralizing antibodies give excellent protection against severe illness, but the immunity wanes over time (within months), noting the virus is known to mutate.
However, the T-cell immunity lasts longer (typically for years), and “probably protects against new strains,” the study found.
CLICK HERE to read the full report from The Guardian.
As an immunologist, my response is yes, what did you expect? This is what our adaptive immune system has been evolving for millions of year to do. It works. Why? When it does not, people die.
Staying positive, it does inform some potential targets. Good.
— Dr J. W. Gill (@JWGill3) November 11, 2021
To get more information about this article, please visit The Guardian.
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